Department of Intensive Care, Southwest Hospital, Third Military Medical University of Chinese PLA, Chongqing, China.
J Clin Neurosci. 2010 Dec;17(12):1530-6. doi: 10.1016/j.jocn.2010.03.060.
We aimed to quantitatively analyze the invasion of glioma cells by diffusion tensor imaging (DTI). Twenty patients with glioma, who required surgical decompression, were included in this study. Peritumoral edematous regional tissues were harvested for tumor cell counting and cell density analysis to establish standards for degrees of tumor infiltration. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of water molecules in brain in five regions of interest (ROI) were measured by DTI: (i) the glioma region; (ii) peritumoral edematous tissue; (iii) surrounding edematous tissue; (iv) white matter; and (v) contralateral white matter. The correlation between FA and ADC values from different ROI, and degree of tumor infiltration was analysed. FA values tended to increase from the glioma region outwards, and the maximum amplification appeared between peritumoral edematous and surrounding edematous regions. FA values from peritumoral edematous regions were negatively correlated with the degree of glioma infiltration. ADC values increased significantly in the peritumoral edematous region, but changes in other regions were variable. FA values from peritumoral edematous regions should be used as an evaluation index for the invasion of glioma cells.
我们旨在通过弥散张量成像（DTI）定量分析脑胶质瘤细胞的浸润。本研究纳入了 20 例需要手术减压的脑胶质瘤患者。对肿瘤周围水肿区域组织进行采集，用于肿瘤细胞计数和细胞密度分析，以建立肿瘤浸润程度的标准。通过 DTI 测量脑五个感兴趣区（ROI）中水分子的各向异性分数（FA）和表观扩散系数（ADC）值：（i）肿瘤区域；（ii）肿瘤周围水肿组织；（iii）周围水肿组织；（iv）白质；和（v）对侧白质。分析了不同 ROI 之间的 FA 和 ADC 值与肿瘤浸润程度之间的相关性。FA 值从肿瘤区域向外呈上升趋势，最大放大出现在肿瘤周围水肿和周围水肿区域之间。肿瘤周围水肿区的 FA 值与胶质瘤浸润程度呈负相关。肿瘤周围水肿区的 ADC 值显著升高，但其他区域的变化则各不相同。肿瘤周围水肿区的 FA 值可作为评估脑胶质瘤细胞浸润的指标。
