通过OsO4/NaIO4/HMTA介导的炔肽氧化裂解进行羧酸和草氨酸的固相合成。
Solid-phase synthesis of carboxylic and oxamic acids via OsO4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides.
作者信息
Nielsen Thomas E, Le Quement Sebastian T, Meldal Morten
机构信息
Carlsberg Laboratory, SPOCC Centre, Gamle Carlsberg Vej 10, DK-2500 Valby, Denmark.
出版信息
Org Lett. 2007 Jun 21;9(13):2469-72. doi: 10.1021/ol070693p. Epub 2007 May 23.
PMID:17518476
Abstract
A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.
摘要
本文介绍了一种通过炔烃的氧化裂解进行羧基官能化肽固相合成的通用方法。向经典的OsO4/NaIO4混合物中添加碱（如DABCO和HMTA）可实现清洁且定量的转化。草氨酸的合成进一步说明了该反应的实用性。
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