Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universitätsstraße 2, 45117 Essen, Germany.
Molecules. 2013 Jan 24;18(2):1337-67. doi: 10.3390/molecules18021337.
Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.
环二肽天然产物通常具有有趣的生物活性，其复杂的分子骨架使它们成为化学合成的有趣目标。虽然环二肽具有高度多样化的化学结构，但它们的合成通常涉及类似的合成挑战，例如建立合适的大环化方法。因此，本综述汇编了不同生物活性环二肽天然产物的合成方法案例研究，从而说明了环二肽合成的障碍及其克服方法。
