A highly alpha-regioselective AgOTf-catalyzed nucleophilic substitution of the Baylis-Hillman acetates with indoles.

作者信息

Shafiq Zahid, Liu Li, Liu Zhe, Wang Dong, Chen Yong-Jun

机构信息

Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.

出版信息

Org Lett. 2007 Jun 21;9(13):2525-8. doi: 10.1021/ol070878w. Epub 2007 May 23.

An efficient method for highly alpha-regioselective nucleophilic substitution of the Baylis-Hillman acetates with indoles catalyzed by AgOTf in high yields (72-99%) has been developed. Reductive cyclization of the substitution products furnished the azepinoindole derivatives in good yields (up to 93%).