HIV感染中CD4+ T细胞耗竭的时间尺度。
Time scales of CD4+ T cell depletion in HIV infection.
作者信息
De Boer Rob J
机构信息
Theoretical Biology group, Utrecht University, Utrecht, The Netherlands.
出版信息
PLoS Med. 2007 May;4(5):e193. doi: 10.1371/journal.pmed.0040193.
Abstract
Rob De Boer discusses a new study that investigated whether a runaway process of T cell activation/infection would be compatible with the slow time scale of memory CD4 T cell depletion in humans with chronic HIV infection.
摘要
罗布·德·布尔讨论了一项新研究，该研究调查了T细胞激活/感染的失控过程是否与慢性HIV感染患者记忆性CD4 T细胞耗竭的缓慢时间尺度相兼容。
相似文献
1
Time scales of CD4+ T cell depletion in HIV infection.HIV感染中CD4+ T细胞耗竭的时间尺度。
PLoS Med. 2007 May;4(5):e193. doi: 10.1371/journal.pmed.0040193.
2
Understanding the slow depletion of memory CD4+ T cells in HIV infection.了解HIV感染中记忆性CD4 + T细胞的缓慢耗竭。
PLoS Med. 2007 May;4(5):e177. doi: 10.1371/journal.pmed.0040177.
3
Modeling HIV infection of CD4+ T-cell subpopulations.CD4+ T细胞亚群的HIV感染建模。
J Theor Biol. 1994 Oct 21;170(4):367-91. doi: 10.1006/jtbi.1994.1199.
4
Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals.模拟HIV感染个体中CD4+ T细胞的缓慢下降
PLoS Comput Biol. 2015 Dec 28;11(12):e1004665. doi: 10.1371/journal.pcbi.1004665. eCollection 2015 Dec.
5
Anti-HIV type 1 memory cytotoxic T lymphocyte responses associated with changes in CD4+ T cell numbers in progression of HIV type 1 infection.
AIDS Res Hum Retroviruses. 1998 Nov 1;14(16):1423-33. doi: 10.1089/aid.1998.14.1423.
6
Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection.CD127表达缺失与HIV感染中的免疫激活及CD4(+) T细胞丧失相关联。
Trends Microbiol. 2008 Dec;16(12):567-73. doi: 10.1016/j.tim.2008.08.011. Epub 2008 Oct 27.
7
CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?HIV感染中CD4+ T细胞耗竭：我们离了解其病因更近了吗？
Nat Med. 2002 Apr;8(4):319-23. doi: 10.1038/nm0402-319.
8
The dynamics of CD4+ T-cell depletion in HIV disease.HIV疾病中CD4+ T细胞耗竭的动态变化。
Nature. 2001 Apr 19;410(6831):974-9. doi: 10.1038/35073648.
9
Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV.维持 CD4+ T 细胞记忆和 HIV 持续存在：保持记忆，保持 HIV。
Curr Opin HIV AIDS. 2011 Jan;6(1):30-6. doi: 10.1097/COH.0b013e3283413775.
10
The disappearing CD4(+)T cells in HIV infection: a case of over-stimulation?HIV感染中CD4(+)T细胞的消失：过度刺激的一个案例？
J Theor Biol. 1999 Apr 21;197(4):507-16. doi: 10.1006/jtbi.1998.0891.
引用本文的文献
1
Defects in immune response to Toxoplasma gondii are associated with enhanced HIV-1-related neurocognitive impairment in co-infected patients.对弓形虫免疫反应的缺陷与合并感染患者中 HIV-1 相关的神经认知障碍的加重有关。
PLoS One. 2023 May 24;18(5):e0285976. doi: 10.1371/journal.pone.0285976. eCollection 2023.
2
The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders.转化生长因子β-1在HIV/AIDS进展及非艾滋病定义性纤维化疾病发展中的作用
Front Immunol. 2017 Nov 2;8:1461. doi: 10.3389/fimmu.2017.01461. eCollection 2017.
3
Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections.HIV-1和HIV-2感染中CD4+ T细胞耗竭的病理生理学
Front Immunol. 2017 May 23;8:580. doi: 10.3389/fimmu.2017.00580. eCollection 2017.
4
Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals.模拟HIV感染个体中CD4+ T细胞的缓慢下降
PLoS Comput Biol. 2015 Dec 28;11(12):e1004665. doi: 10.1371/journal.pcbi.1004665. eCollection 2015 Dec.
5
Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism.在人类 HIV-1 感染中，无论病毒趋化因子共受体嗜性如何，记忆表型 CD4+ T 细胞的体内增殖均加速。
PLoS Pathog. 2013;9(4):e1003310. doi: 10.1371/journal.ppat.1003310. Epub 2013 Apr 18.
6
Dynamic models of immune responses: what is the ideal level of detail?免疫反应的动态模型：理想的详细程度是多少？
Theor Biol Med Model. 2010 Aug 20;7:35. doi: 10.1186/1742-4682-7-35.
7
CD 4+ T cells in the pathobiology of neurodegenerative disorders.CD4+ T细胞在神经退行性疾病的病理生物学中（的作用）。
J Neuroimmunol. 2009 Jun 25;211(1-2):3-15. doi: 10.1016/j.jneuroim.2009.04.006. Epub 2009 May 12.
本文引用的文献
1
Estimating the role of thymic output in HIV infection.估算胸腺输出在 HIV 感染中的作用。
Curr Opin HIV AIDS. 2006 Jan;1(1):16-21. doi: 10.1097/01.COH.0000194105.12816.6a.
2
Understanding the slow depletion of memory CD4+ T cells in HIV infection.了解HIV感染中记忆性CD4 + T细胞的缓慢耗竭。
PLoS Med. 2007 May;4(5):e177. doi: 10.1371/journal.pmed.0040177.
3
Quantification of T-cell dynamics: from telomeres to DNA labeling.T细胞动力学的量化：从端粒到DNA标记
Immunol Rev. 2007 Apr;216:35-47. doi: 10.1111/j.1600-065X.2007.00497.x.
4
Perils at mucosal front lines for HIV and SIV and their hosts.HIV和SIV及其宿主在黏膜前沿面临的风险。
Nat Rev Immunol. 2005 Oct;5(10):783-92. doi: 10.1038/nri1706.
5
Uses and abuses of mathematics in biology.数学在生物学中的应用与滥用。
Science. 2004 Feb 6;303(5659):790-3. doi: 10.1126/science.1094442.
6
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.晚期HIV-1感染中长寿命和短寿命T细胞的亚群
J Clin Invest. 2003 Sep;112(6):956-66. doi: 10.1172/JCI17533.
7
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.尽管存在慢性高水平病毒血症，但黑猩猩感染非致病性猴免疫缺陷病毒的特征是旁观者免疫病理学有限。
Immunity. 2003 Mar;18(3):441-52. doi: 10.1016/s1074-7613(03)00060-8.
8
Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques.感染和未感染猿猴免疫缺陷病毒的恒河猴中B细胞、T细胞和NK细胞的周转率
J Immunol. 2003 Mar 1;170(5):2479-87. doi: 10.4049/jimmunol.170.5.2479.
9
CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?HIV感染中CD4+ T细胞耗竭：我们离了解其病因更近了吗？
Nat Med. 2002 Apr;8(4):319-23. doi: 10.1038/nm0402-319.
10
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.在晚期人类免疫缺陷病毒1型感染中，生存期较短与T淋巴细胞激活的关联比与血浆病毒载量或病毒趋化因子共受体使用情况的关联更为密切。
J Infect Dis. 1999 Apr;179(4):859-70. doi: 10.1086/314660.
Zotero 插件