Beck Jonathan, Angus Ryan, Madsen Ben, Britt David, Vernon Brent, Nguyen Kytai T
Department of Biological and Irrigation Engineering, Utah State University, Logan, Utah, USA.
Tissue Eng. 2007 Mar;13(3):589-99. doi: 10.1089/ten.2006.0183.
Diabetes is one of the most prevalent, costly, and debilitating diseases in the world. Although traditional insulin therapy has alleviated the short-term effects, long-term complications are ubiquitous and harmful. For these reasons, alternative treatment options are being developed. This review investigates one appealing area: cell replacement using encapsulated islets. Encapsulation materials, encapsulation methods, and cell sources are presented and discussed. In addition, the major factors that currently limit cell viability and functionality are reviewed, and strategies to overcome these limitations are examined. This review is designed to introduce the reader to cell replacement therapy and cell and tissue encapsulation, especially as it applies to diabetes.
糖尿病是世界上最普遍、代价高昂且使人衰弱的疾病之一。尽管传统胰岛素疗法缓解了短期影响，但长期并发症却普遍存在且有害。出于这些原因，正在研发替代治疗方案。本综述研究了一个有吸引力的领域：使用封装胰岛进行细胞替代。介绍并讨论了封装材料、封装方法和细胞来源。此外，回顾了目前限制细胞活力和功能的主要因素，并研究了克服这些限制的策略。本综述旨在向读者介绍细胞替代疗法以及细胞和组织封装，特别是其在糖尿病治疗中的应用。
