Ingber Donald E, Mow Van C, Butler David, Niklason Laura, Huard Johnny, Mao Jeremy, Yannas Ioannis, Kaplan David, Vunjak-Novakovic Gordana
Vascular Biology Program, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Tissue Eng. 2006 Dec;12(12):3265-83. doi: 10.1089/ten.2006.12.3265.
This article contains the collective views expressed at the first session of the workshop "Tissue Engineering--The Next Generation," which was devoted to the interactions between developmental biology and tissue engineering. Donald Ingber discussed the chasms between developmental biology and tissue engineering from the perspective of a cell biologist who has had interest in tissue engineering since its early days. Van C. Mow shared a historical perspective on the development of tissue engineering as one of the first engineers involved in the field. David Butler offered an assessment of functional tissue engineering, a new area he helped establish and promote. Laura Niklason discussed how to be more effective in developing cellular therapies for large numbers of patients. Johnny Huard described his approach to tissue engineering, based on the use of muscle-derived cells. Jeremy Mao focused on cell homing and cell density in the context of native development and relevance to tissue engineering. Ioannis Yannas proposed a set of "rules" in organ regeneration. Collectively, the faculty expressed a remarkable level of enthusiasm for bridging the gaps between developmental biology and tissue engineering and offered new ideas on how to facilitate the interaction between the two fields.
本文包含了在“组织工程——下一代”研讨会第一次会议上表达的集体观点，该研讨会致力于发育生物学与组织工程之间的相互作用。唐纳德·英格伯从一位自组织工程早期就对其感兴趣的细胞生物学家的角度，探讨了发育生物学与组织工程之间的差距。范·C·莫作为最早参与该领域的工程师之一，分享了组织工程发展的历史视角。大卫·巴特勒对功能组织工程进行了评估，这是他帮助建立和推动的一个新领域。劳拉·尼克拉斯森讨论了如何更有效地为大量患者开发细胞疗法。约翰尼·胡德描述了他基于使用肌肉衍生细胞的组织工程方法。杰里米·毛在天然发育的背景下以及与组织工程的相关性方面，重点关注细胞归巢和细胞密度。约阿尼斯·扬纳斯提出了一套器官再生的“规则”。总体而言，与会教员对弥合发育生物学与组织工程之间的差距表现出了极高的热情，并就如何促进这两个领域之间的相互作用提出了新的想法。
