Liao Weifang, Shi Yuying, Li Zuguang, Yin Xiaoping
Department of Medical Laboratory, Affiliated Hospital of Jiujiang University, Jiujiang, China.
Jiujiang Clinical Precision Medicine Research Center, Jiujiang, China.
J Nanobiotechnology. 2025 Jan 3;23(1):5. doi: 10.1186/s12951-024-03052-9.
The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. Tissue engineering offers a promising avenue for overcoming the limitations of conventional treatments and increasing the outcomes of regenerative repair. By implanting scaffolds into damaged nerve tissue sites, the repair and functional reconstruction of nerve injuries can be significantly facilitated. The integration of three-dimensional (3D) printing technology introduces a novel approach for accurate simulation and scalably fabricating neural tissue structures. Tissue-engineered scaffolds developed through 3D printing technology are expected to be a viable therapeutic option for nerve injuries, with broad applicability and continued development. This review systematically examines recent advances in 3D printing and tissue engineering for nerve regeneration and repair. It details the basic principles and construction strategies of neural tissue engineering and explores the crucial role of 3D printing technology. Additionally, it elucidates specific applications and technical challenges associated with this integrated approach, thereby providing valuable insights into innovative strategies and pragmatic implementation within this field.
由于神经的自我修复能力有限以及其高度分化的性质，神经损伤的修复长期以来一直是一项挑战。虽然神经病学领域出现了新的治疗和药物干预措施，但其再生效果仍然有限。组织工程为克服传统治疗的局限性和提高再生修复效果提供了一条有前景的途径。通过将支架植入受损神经组织部位，可以显著促进神经损伤的修复和功能重建。三维（3D）打印技术的融入引入了一种精确模拟和可扩展制造神经组织结构的新方法。通过3D打印技术开发的组织工程支架有望成为治疗神经损伤的可行选择，具有广泛的适用性和持续发展潜力。本文综述系统地研究了3D打印和组织工程在神经再生与修复方面的最新进展。详细阐述了神经组织工程的基本原理和构建策略，并探讨了3D打印技术的关键作用。此外，阐明了与这种综合方法相关的具体应用和技术挑战，从而为该领域的创新策略和实际应用提供了有价值的见解。
