Shiboski Caroline H, Schmidt Brian L, Jordan Richard C K
Department of Orofacial Sciences, Division of Oral Pathology, Oral Medicine, Oral Radiology, School of Dentistry, University of California San Francisco, San Francisco, CA 94143-0422, USA.
Community Dent Oral Epidemiol. 2007 Jun;35(3):233-40. doi: 10.1111/j.0301-5661.2007.00334.x.
To explore distribution of stage at diagnosis and relative survival rates among US adults with oral cavity cancer in relation to race, and over time.
We obtained 1973-2002 oral cancer incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program, and computed proportions for each oral cavity site by stage at diagnosis, tumor size, and 5-year relative survival rates among Whites and Blacks.
A total of 46 855 cases of oral cavity cancer were reported to the SEER registry among adults > or =20 years between 1973 and 2002. African-Americans had a significantly higher proportion of cancer, mainly in the tongue, that had spread to a regional node or to a distant site at diagnosis than Whites: 67% versus 49% of tongue cancers reported from 1973 to 1987 (P < 0.001), and 70% versus 53% of those reported from 1988 to 2002 (P < 0.001). They had a significantly higher proportion of tongue cancer that were >4 cm in diameter at time of diagnosis (59% versus 44%; P < 0.001), and black men in particular experienced lower 5-year relative survival rates than white men, in particular, for tongue cancer (25% versus 43% from 1973 to 1987, and 31% versus 53% from 1988 to 2002).
There are significant racial disparities with respect to stage at diagnosis and survival among adults with oral cancer reported to the SEER registry from 1973 to 2002. One possible explanation for the lower survival among Blacks may be a difference in access to, and utilization of, healthcare services.
探讨美国口腔癌成年患者确诊时的分期分布及相对生存率与种族的关系，以及随时间的变化情况。
我们从监测、流行病学和最终结果（SEER）项目中获取了1973 - 2002年口腔癌发病数据，并按确诊时的分期、肿瘤大小计算了白人和黑人中每个口腔部位的比例以及5年相对生存率。
1973年至2002年期间，SEER登记处共报告了46855例年龄≥20岁的成年口腔癌病例。非裔美国人确诊时已扩散至区域淋巴结或远处部位的癌症比例显著高于白人，主要集中在舌部：1973年至1987年报告的舌癌病例中，这一比例分别为67%和49%（P < 0.001）；1988年至2002年报告的病例中，这一比例分别为70%和53%（P < 0.001）。他们确诊时直径>4 cm的舌癌比例显著更高（59%对44%；P < 0.001），尤其是黑人男性的5年相对生存率低于白人男性，特别是舌癌（1973年至1987年为25%对43%，1988年至2002年为31%对53%）。
1973年至2002年向SEER登记处报告的成年口腔癌患者在确诊时的分期和生存率方面存在显著的种族差异。黑人生存率较低的一个可能原因是医疗服务的可及性和利用率存在差异。
