de Luca C, Deeva I, Mikhal'Chik E, Korkina L
Lab. Tissue Engineering & Cutaneous Physiopathology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
Cell Mol Biol (Noisy-le-grand). 2007 Apr 15;53(1):94-101.
Modern technologies of skin rejuvenation include many physical and chemical intervention tools--laser irradiation, oxygen and ozone therapy, chemical peels, plastic surgery operations--affecting by different mechanisms the sensitive physiological free radical/antioxidant balance in the skin. All these interventions induce from mild to severe tissue damage, providing beneficial biochemical stimuli for skin re-epithelization and rejuvenation. Paradoxically, free radical production in the course of tissue inflammation helps to combat free radical damage consequent to the ageing process. We have studied two animal models (experimental burn and trichloracetic peeling), reproducing on the Wistar rat the effects generated by the commonly practiced aesthetic medicine procedures of laser resurfacing and chemical peels, demonstrating that the severe oxidative stress induced both systemically and on skin can be modulated by the oral pre- and post treatment administration of specific nutraceutical formulations. Potent antioxidants (RRR-alpha-tocopherol, coenzyme Q10), enhancing antioxidant defences, coupled with mild pro-oxidants, enhancers of a specific immune defense (soy phospholipids, L-methionine), at the blood and the skin levels, proved in fact to be beneficial in vivo, on the rat, for skin healing, trophism and accelerated re-epithelization. Data obtained allow us to predict the possibility of innovative protocols for dermocosmetology, enabling successful lowering of the risk of permanent adverse effects, and prolonging the duration of the beneficial effects of dermocosmetologic procedures.
现代皮肤年轻化技术包括许多物理和化学干预手段——激光照射、氧气和臭氧疗法、化学换肤、整形手术——通过不同机制影响皮肤中敏感的生理自由基/抗氧化剂平衡。所有这些干预都会引发从轻度到重度的组织损伤，为皮肤重新上皮化和年轻化提供有益的生化刺激。矛盾的是，组织炎症过程中产生的自由基有助于对抗衰老过程导致的自由基损伤。我们研究了两种动物模型（实验性烧伤和三氯乙酸换肤），在Wistar大鼠身上再现了常见的美容医学激光换肤和化学换肤程序所产生的效果，证明全身和皮肤诱导的严重氧化应激可以通过口服特定的营养制剂进行预处理和后处理来调节。强效抗氧化剂（RRR-α-生育酚、辅酶Q10）可增强抗氧化防御，再加上轻度促氧化剂、特定免疫防御增强剂（大豆磷脂、L-甲硫氨酸），在血液和皮肤水平上，实际上已证明对大鼠体内的皮肤愈合、营养状况和加速重新上皮化有益。所获得的数据使我们能够预测皮肤美容学创新方案的可能性，成功降低永久性不良反应的风险，并延长皮肤美容程序有益效果的持续时间。
