Cookson J C
Joint Academic Unit of Human Psychopharmacology, Royal London Hospital, England.
Clin Neuropharmacol. 1991;14 Suppl 2:S24-30; discussion S30-2.
During long-term treatment of schizophrenia with antipsychotic medication, side effects such as weight gain and tardive dyskinesia may develop, while other extrapyramidal side effects may continue. A large multicenter, double-blind, comparative trial of haloperidol decanoate and fluphenazine decanoate has been completed, in which 181 patients took part. The study lasted for 1 year and patients were assessed using the Krawiecka scale, the Montgomery-Asberg scales for schizophrenia and depression, the Simpson-Angus scale for parkinsonism, the AIMS for tardive dyskinesia, and a scale for akathisia. Patients were also weighed at each assessment. The results provide further evidence about the occurrence of weight changes, extrapyramidal side effects, and depression during long-term treatment and about the relative benefits of the two treatments.
在使用抗精神病药物对精神分裂症进行长期治疗期间，可能会出现体重增加和迟发性运动障碍等副作用，而其他锥体外系副作用可能会持续存在。一项关于癸酸氟哌啶醇和癸酸氟奋乃静的大型多中心、双盲、对照试验已经完成，共有181名患者参与。该研究持续了1年，使用克拉维茨卡量表、精神分裂症和抑郁症的蒙哥马利-阿斯伯格量表、帕金森症的辛普森-安格斯量表、迟发性运动障碍的异常不自主运动量表以及静坐不能量表对患者进行评估。每次评估时还会对患者进行称重。结果为长期治疗期间体重变化、锥体外系副作用和抑郁症的发生以及两种治疗方法的相对益处提供了进一步的证据。
