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Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides.

作者信息

Bernardo D, Garrote J A, Fernández-Salazar L, Riestra S, Arranz E

出版信息

Gut. 2007 Jun;56(6):889-90. doi: 10.1136/gut.2006.118265.

DOI:10.1136/gut.2006.118265
PMID:17519496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1954879/
Abstract
摘要

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Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides.麦醇溶蛋白对非乳糜泻个体真的安全吗？用麦醇溶蛋白肽刺激非乳糜泻个体的活检组织培养物中白细胞介素15的产生。
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本文引用的文献

1
Mechanisms of disease: immunopathogenesis of celiac disease.疾病机制：乳糜泻的免疫发病机制
Nat Clin Pract Gastroenterol Hepatol. 2006 Sep;3(9):516-25. doi: 10.1038/ncpgasthep0582.
2
Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease.上皮来源的白细胞介素15调节乳糜泻中上皮内淋巴细胞Th1细胞因子的产生、细胞毒性和存活。
Gut. 2006 Apr;55(4):469-77. doi: 10.1136/gut.2005.068684. Epub 2005 Aug 16.
3
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.白细胞介素15对不依赖T细胞受体的自然杀伤细胞2D（NKG2D）信号通路的协同诱导，可将腹腔疾病中的细胞毒性T淋巴细胞转化为淋巴因子激活的杀伤细胞。
Immunity. 2004 Sep;21(3):357-66. doi: 10.1016/j.immuni.2004.06.020.
4
Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease.乳糜泻中对麦醇溶蛋白的固有反应与致病性T细胞激活之间的关联。
Lancet. 2003 Jul 5;362(9377):30-7. doi: 10.1016/S0140-6736(03)13803-2.