Genkova-Papazova Maria, Petkova B, Stankova I, Ossowska K, Lazarova-Bakarova M
Laboratory CNS Pharmacology, Institute of Physiology by the Bulgarian Academy of Sciences, Sofia, Bulgaria.
Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):205-9. doi: 10.1358/mf.2007.29.3.1075356.
In recent years metabotropic glutamate receptors (mGluRs) have received considerable attention as a potential target for psychotropic drugs, but their influence on learning and memory is still unclear. The aim of the present study was to examine whether intraperitoneal (i.p.) administration of selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyrydine (MPEP), injected prior to, immediately after or 30 min after training, affects acquisition and/or retrieval of the inhibitory step-down and active shuttle-box avoidance in rats. Our results indicate that 5 or 10 mg/kg i.p. MPEP in all tested groups impaired memory consolidation of step-down training without affecting acquisition and had no effect on learning and retention in shuttle-box trained rats. The data are in agreement with the statement that mGluR5s may contribute very little and task-dependently to the actual acquisition of new information, but memory formation, appears to require mGluR5s through modulation of consolidation and/or recall.
近年来，代谢型谷氨酸受体（mGluRs）作为精神药物的潜在靶点受到了广泛关注，但其对学习和记忆的影响仍不明确。本研究的目的是考察在训练前、训练后立即或训练后30分钟腹腔注射选择性mGluR5拮抗剂2-甲基-6-（苯乙炔基）吡啶（MPEP）是否会影响大鼠抑制性阶梯式下降和主动穿梭箱回避的习得和/或记忆提取。我们的结果表明，在所有测试组中，腹腔注射5或10mg/kg的MPEP会损害阶梯式下降训练的记忆巩固，而不影响习得，并且对穿梭箱训练大鼠的学习和记忆保持没有影响。这些数据与以下观点一致，即mGluR5s对新信息的实际习得可能贡献很小且依赖于任务，但记忆形成似乎需要通过对巩固和/或回忆的调节来实现mGluR5s的参与。
