氨基酰 - S - 酶中间体的形成是氯霉素生物合成中的关键步骤。
Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol.
作者信息
Pacholec Michelle, Sello Jason K, Walsh Christopher T, Thomas Michael G
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
出版信息
Org Biomol Chem. 2007 Jun 7;5(11):1692-4. doi: 10.1039/b703356g. Epub 2007 Apr 26.
DOI:10.1039/b703356g
PMID:17520135
Abstract
Herein we report the first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol that provides new insights into the origins of the antibiotic.
摘要
在此，我们报告了参与氯霉素生物合成的一种酶的首次生化特性分析，这为该抗生素的起源提供了新的见解。
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