Rettmann Dan W, Saranathan Manojkumar, Wu Katherine C, Azevedo Clerio F, Bluemke David A, Foo Thomas K F
Applied Science Laboratory, GE Healthcare, 200 First Street SW, Rochester, MN 55905, USA.
J Magn Reson Imaging. 2007 Jun;25(6):1141-6. doi: 10.1002/jmri.20923.
To develop a gated single-breathhold, high temporal resolution three-dimensional (3D) CINE imaging technique and to evaluate its accuracy in volumetric and functional quantification in patients with chronic myocardial infarction.
A 3D CINE steady-state free precession (SSFP) pulse sequence was developed incorporating variable temporal sampling of the low and high spatial frequency k-space data to reduce breathhold time and parallel imaging to increase temporal resolution. Reconstruction with retrospective interpolation enabled complete R-R interval coverage. Feasibility was assessed in eight patients with chronic myocardial infarction and ventricular functional values were compared to those of a 2D CINE acquisition.
There was no significant difference between the 3D CINE and 2D CINE for end-diastolic volume (168 +/- 73 vs. 177 +/- 59 mL, respectively; P < 0.27), end-systolic volume (81 +/- 62 vs. 79 +/- 53 mL; P < 0.81), and ejection fraction (EF) measurements (55 +/- 14% vs. 58 +/- 14%; P < 0.14). The mean difference in EF was less than 2.5%. A wall motion assessment indicated a good agreement, with a weighted kappa value of 0.62.
High temporal resolution 3D CINE SSFP imaging of the whole heart can be obtained in a single breathhold and yield ventricular function measurements similar to 2D CINE methods.
开发一种门控单屏气、高时间分辨率的三维（3D）电影成像技术，并评估其在慢性心肌梗死患者容积和功能定量分析中的准确性。
开发了一种3D电影稳态自由进动（SSFP）脉冲序列，该序列结合了对低空间频率和高空间频率k空间数据的可变时间采样，以减少屏气时间，并采用并行成像来提高时间分辨率。通过回顾性插值重建可实现完整的R-R间期覆盖。对8例慢性心肌梗死患者进行可行性评估，并将心室功能值与二维电影采集的结果进行比较。
3D电影成像和二维电影成像在舒张末期容积（分别为168±73和177±59 mL；P<0.27）、收缩末期容积（81±62和79±53 mL；P<0.81）和射血分数（EF）测量值（55±14%和58±14%；P<0.14）方面无显著差异。EF的平均差异小于2.5%。壁运动评估显示一致性良好，加权kappa值为0.62。
单次屏气即可获得全心脏的高时间分辨率3D电影SSFP成像，其心室功能测量结果与二维电影成像方法相似。
