Connelly Kim A, Detsky Jay S, Graham John J, Paul Gideon, Vijayaragavan Ram, Dick Alexander J, Wright Graham A
Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
J Magn Reson Imaging. 2009 Oct;30(4):771-7. doi: 10.1002/jmri.21907.
To determine the accuracy of multicontrast late enhancement imaging (MCLE) in the assessment of myocardial viability and wall motion compared to the conventional wall motion and viability cardiac magnetic resonance imaging (MRI) pulse sequences.
Forty-one patients with suspected myocardial infarction were studied. Patients underwent assessment of cardiac function with cine steady-state free-precession (SSFP), followed by late gadolinium enhancement (LGE) imaging using inversion recovery gradient echo scanning (IR-GRE) sequence and MCLE. MCLE was compared to cine SSFP in the assessment of wall motion, ejection fraction (EF), left ventricular (LV) mass, LV end-diastolic volume (EDV), and to IR-GRE for measuring infarct size.
MCLE, IR-GRE, and SSFP imaging demonstrated excellent agreement in the assessment of EF, LV infarct size, and LV mass (r > 0.95, P < 0.001 for all measures), as well as in the assessment of wall motion (kappa statistic 0.75).
MCLE provided coregistered images for the assessment of viability and wall motion without loss of accuracy in the assessment of quantitative cardiac parameters. MCLE provides accurate quantitative cardiac assessment with reduced scan times compared to the conventional sequences and thus may be used as an alternative to conventional cine SSFP and IR-GRE imaging.
与传统的心脏壁运动及心肌存活心脏磁共振成像（MRI）脉冲序列相比，确定多对比延迟增强成像（MCLE）在评估心肌存活及壁运动方面的准确性。
对41例疑似心肌梗死患者进行研究。患者先采用电影稳态自由进动（SSFP）序列评估心脏功能，随后使用反转恢复梯度回波扫描（IR-GRE）序列及MCLE进行钆延迟增强（LGE）成像。将MCLE在评估壁运动、射血分数（EF）、左心室（LV）质量、左心室舒张末期容积（EDV）方面与电影SSFP进行比较，在测量梗死面积方面与IR-GRE进行比较。
MCLE、IR-GRE及SSFP成像在评估EF、左心室梗死面积及左心室质量方面（所有测量指标r>0.95，P<0.001）以及在评估壁运动方面（kappa统计量为0.75）显示出高度一致性。
MCLE提供了用于评估存活及壁运动的配准图像，在定量心脏参数评估中不失准确性。与传统序列相比，MCLE能以更短的扫描时间提供准确的定量心脏评估，因此可作为传统电影SSFP及IR-GRE成像的替代方法。
