Kang Lu, Zhou Jian-Xia, Shen Zheng-Wu
Shanghai University of Traditional Chinese Medicine, Shanghai 200233, China.
Yao Xue Xue Bao. 2007 Jan;42(1):58-60.
The aim of this study was to look for the chemical constituents of the bulbs of Fritillaria anhuiensis S. C. Chen et S. E. Yin. The bulbs of Fritillaria anhuiensis were extracted with 95% EtOH at reflux. Isolation and purification were performed by silica gel column chromatography. Structures of pure compounds were established on the basis of spectral analysis. Three compounds were obtained and identified as 12,15-epoxy-8(17), 13-labdadien-19-ol (1), ent-3beta-acetoxy-kauran-16beta, 17-diol (2), ent-kaurane-3beta, 16beta, 17-triol (3). Compound 1 is a new labdane-type diterpenoid. Compounds 2 and 3 were obtained from Fritillaria anhuiensis for the first time.
本研究旨在探寻安徽贝母（Fritillaria anhuiensis S. C. Chen et S. E. Yin）鳞茎的化学成分。采用95%乙醇对安徽贝母鳞茎进行回流提取。通过硅胶柱色谱进行分离纯化。基于光谱分析确定纯化合物的结构。得到了3个化合物，分别鉴定为12,15-环氧-8(17),13-赖百当二烯-19-醇（1）、对映-3β-乙酰氧基-贝壳杉烷-16β,17-二醇（2）、对映-贝壳杉烷-3β,16β,17-三醇（3）。化合物1是一种新的半日花烷型二萜。化合物2和3首次从安徽贝母中获得。
