[格里菲斯素对癌细胞体外抗癌活性及凋亡的影响]
[Effect of griffithin on anticancer activity and apoptosis of cancer cells in vitro].
作者信息
Luan Lian-Jun, Wang Ye-Fei, Zhang Lin, Wu Yong-Jiang
机构信息
Institute of Modern Chinese Medicine, Zhejiang University, Hangzhou 310058, China.
出版信息
Yao Xue Xue Bao. 2007 Jan;42(1):104-7.
To study the anticancer activity of griffithin from Streptocaulon griffithii Hook. f. and its effect on apoptosis of cancer cells in vitro, the inhibitory effect of griffithin on cell proliferation was studied by MTT assay, the cell apoptosis was observed by AO/EB double decoration assay and flow cytometry. Griffithin exhibited high anticancer activity on four human cancer cell lines, with IC50 ranged from 0.17 - 0.43 microg x mL(-1). Griffithin also induced apoptosis of PC-3 cells. Griffithin had anticancer activity and induced apoptosis of cancer cells.
为研究大理菊链珠藤（Streptocaulon griffithii Hook. f.）中分离得到的格里菲因的体外抗癌活性及其对癌细胞凋亡的影响，采用MTT法研究格里菲因对细胞增殖的抑制作用，采用AO/EB双染法和流式细胞术观察细胞凋亡情况。结果表明，格里菲因对四种人癌细胞系具有较高的抗癌活性，IC50范围为0.17 - 0.43μg·mL-1。格里菲因还能诱导PC-3细胞凋亡。格里菲因具有抗癌活性并能诱导癌细胞凋亡。
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