Wang Tian-Min, Hojo Toshinari, Ran Fu-Xiang, Wang Ru-Feng, Wang Rui-Qing, Chen Hu-Biao, Cui Jing-Rong, Shang Ming-Ying, Cai Shao-Qing
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
J Nat Prod. 2007 Sep;70(9):1429-33. doi: 10.1021/np070150o. Epub 2007 Sep 11.
Three new cardenolides, 3-O-beta-D-fucopyranosylstrophanthidin (1), 3-O-beta-D-quinovopyranosylperiplogenin (2), and 3-O-beta-D-glucopyranosyl-(1 --> 4)-alpha- l-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4- 10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2- 10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC 50 values of <1 microM for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.
从紫苞风毛菊全株干燥植物的细胞毒性乙醇提取物中分离出三种新的强心苷，即3-O-β-D-岩藻糖基毒毛旋花子苷元（1）、3-O-β-D-奎诺糖基杠柳毒苷元（2）和3-O-β-D-葡萄糖基-(1→4)-α-L-鼠李糖基甘遂二萜酯（3），以及七种已知的强心苷（4-10）。这些化合物的结构通过光谱和化学方法确定。当评估化合物2-10对Bel-7402人肝癌细胞和BGC-823人胃癌细胞的细胞毒性时，所有化合物对这两种细胞系的IC50值均<1μM。这是菊科植物中首次报道存在强心苷。
