Song Min, Hang Tai-Jun, Zhang Zheng-Xing
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Yao Xue Xue Bao. 2007 Mar;42(3):301-7.
The pharmacokinetics of the main components of protocatechualdehyde, salvianolic acid B, tanshinone II(A), cryptotanshinone, and the hydrophilic or lipophilic extracts of Salvia Miltiorrhiza Bge., in rat plasma were studied after oral administration separately to explore the interactions between them. Some components in the hydrophilic extract depress the absorption of the protocatechualdehyde, on the contrary, enhance the absorption of the salvianolic acid B and depress its elimination rate. The concomitant components in the lipophilic extract might enhance the absorption of cryptotanshinone and its distribution from the centre compartment to the peripheral compartment, and the metabolism to tanshinone II(A). The 'concomitant components' in the extract of Chinese material medica had significant effect on the pharmacokinetics of its 'marker components'. It can not only be rival, synergic, but also have the effects on metabolism. Therefore the traditional Chinese medicine was a complicated system, It should be taken a scientific and dialectic view in the research and development processes.
分别对大鼠口服丹参中原儿茶醛、丹酚酸B、丹参酮ⅡA、隐丹参酮以及亲水性或亲脂性提取物的主要成分进行药代动力学研究，以探讨它们之间的相互作用。亲水性提取物中的某些成分会抑制原儿茶醛的吸收，相反，会增强丹酚酸B的吸收并降低其消除速率。亲脂性提取物中的伴随成分可能会增强隐丹参酮的吸收及其从中央室到外周室的分布，以及向丹参酮ⅡA的代谢。中药材提取物中的“伴随成分”对其“标记成分”的药代动力学有显著影响。它不仅可以是竞争性的、协同性的，还可以对代谢产生影响。因此，中药是一个复杂的体系，在研发过程中应采取科学辩证的观点。
