Akopian Gabriel, Gaspard Donald J, Alexander Magdi
Huntington Memorial Hospital, Pasadena, California 91105, USA.
Am Surg. 2007 May;73(5):447-50.
Although guidelines exist for intracranial pressure (ICP)-guided treatment after head trauma, no conclusive data exist that support routine ICP monitoring. A retrospective case series was reviewed of all patients admitted to the intensive care unit with a diagnosis of blunt head trauma between January 1, 1999 and December 31, 2004. None of the patients in the final analysis had ICP monitoring. Data collected included age, sex, mechanism of injury, Glasgow Coma Score (GCS) at admission, injury severity score, disposition, and length of stay. One hundred thirty-one patients with a median age of 41 years were included. There were 104 men (79%). The median GCS at admission was 12. There were 22 deaths (17% mortality). Stepwise logistic regression analysis identified older age, higher injury severity score, and lower GCS to be predictors of death. The mortality rate was higher in patients with GCS < or =8 compared with GCS >8 (33% vs 8%, respectively; P < 0.001). Ten of 23 patients with a GCS of 3 died (43% mortality). The median time to death for patients with a GCS of 3 was 2 days. Although the Brain Trauma Foundation has published guidelines advocating routine ICP monitoring, no large randomized prospective studies are available to determine its effect on outcome. None of the patients in this study had ICP monitoring. Our overall survival rate of 83 per cent is relatively high. Patients with a low GCS and, specifically, those with a GCS of 3 may not benefit from ICP monitoring because of early and irreversible trauma. Variability in the use of ICP monitoring will remain until ICP monitoring can be conclusively proven to improve outcome.
尽管存在关于颅脑外伤后颅内压(ICP)引导治疗的指南,但尚无确凿数据支持常规ICP监测。回顾性分析了1999年1月1日至2004年12月31日期间入住重症监护病房且诊断为钝性颅脑外伤的所有患者的病例系列。最终分析中的患者均未进行ICP监测。收集的数据包括年龄、性别、损伤机制、入院时的格拉斯哥昏迷评分(GCS)、损伤严重程度评分、处置方式和住院时间。纳入了131例患者,中位年龄为41岁。男性104例(79%)。入院时的中位GCS为12分。有22例死亡(死亡率17%)。逐步逻辑回归分析确定年龄较大、损伤严重程度评分较高和GCS较低是死亡的预测因素。与GCS>8的患者相比,GCS≤8的患者死亡率更高(分别为33%和8%;P<0.001)。23例GCS为3分的患者中有10例死亡(死亡率43%)。GCS为3分的患者的中位死亡时间为2天。尽管脑外伤基金会已发布提倡常规ICP监测的指南,但尚无大型随机前瞻性研究来确定其对预后的影响。本研究中的患者均未进行ICP监测。我们83%的总生存率相对较高。GCS较低的患者,特别是GCS为3分的患者,可能因早期和不可逆转的创伤而无法从ICP监测中获益。在ICP监测能够被确凿证明可改善预后之前,其使用的变异性仍将存在。