Ogata Fusa, Azuma Ryuichi, Kikuchi Makoto, Koshima Isao, Morimoto Yuji
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Japan.
Ann Plast Surg. 2007 Jun;58(6):652-5. doi: 10.1097/01.sap.0000250896.42800.a2.
Lymphedema is known to be caused by many pathologic conditions; however, its diagnostic and therapeutic strategies remain to be unestablished. In this study, we investigated the usefulness of a novel lymphographic method based on fluorometric sensing using indocyanine green (ICG) dye for imaging lymphatic vessels using rat models. The real-time imaging system enabled visualization of superficial lymphatic vessels with a diameter of 0.1 mm in 33 frames/second. In addition, morphologic changes in lymphatic vessels in a radiation-induced lymphedema model were detected even at the latent stage. These results suggest that this imaging technique is acceptable as an evaluation method for the lymphatic system.
已知淋巴水肿由多种病理状况引起；然而，其诊断和治疗策略仍未确立。在本研究中，我们使用大鼠模型研究了一种基于荧光传感的新型淋巴造影方法的实用性，该方法使用吲哚菁绿（ICG）染料对淋巴管进行成像。实时成像系统能够以每秒33帧的速度可视化直径为0.1毫米的浅表淋巴管。此外，即使在辐射诱导的淋巴水肿模型的潜伏期，也能检测到淋巴管的形态变化。这些结果表明，这种成像技术可作为一种评估淋巴系统的方法。
