Zaidi Sayyed K, Young Daniel W, Javed Amjad, Pratap Jitesh, Montecino Martin, van Wijnen Andre, Lian Jane B, Stein Janet L, Stein Gary S
University of Massachusetts Medical School and UMASS Memorial Cancer Center, Worcester, Massachusetts, USA.
Nat Rev Cancer. 2007 Jun;7(6):454-63. doi: 10.1038/nrc2149.
Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.
核酸和调节蛋白在细胞核内的微环境中被分隔开来。这种核内亚结构组织可能有助于生理信号的汇聚和整合，以对基因表达、DNA复制和修复进行组合控制。在许多癌症中，核组织会发生改变。在核内位点，调节复合物的组成、组织和组装存在与癌症相关的变化。对肿瘤中受损的细胞核内基因表达机制的时间和空间组织的深入了解，为诊断和治疗提供了一个新的平台。
