Zou Ying, Zheng Hongmei, Ning Yue, Yang Yang, Wen Qiuyuan, Fan Songqing
Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Cell Biosci. 2023 Aug 14;13(1):150. doi: 10.1186/s13578-023-01101-8.
Lung cancer is a complex and heterogeneous disease characterized by abnormal growth and proliferation of lung cells. It is the leading cause of cancer-related deaths worldwide, accounting for approximately 18% of all cancer deaths. In recent years, targeted therapy has emerged as a promising approach to treat lung cancer, which involves the use of drugs that selectively target specific molecules or signaling pathways that are critical for the growth and survival of cancer cells. Liquid-liquid phase separation (LLPS) is a fundamental biological process that occurs when proteins and other biomolecules separate into distinct liquid phases in cells. LLPS is essential for various cellular functions, including the formation of membraneless organelles, the regulation of gene expression, and the response to stress and other stimuli. Recent studies have shown that LLPS plays a crucial role in targeted therapy of lung cancer, including the sequestration of oncogenic proteins and the development of LLPS-based drug delivery systems. Understanding the mechanisms of LLPS in these processes could provide insights into new therapeutic strategies to overcome drug resistance in lung cancer cells.
肺癌是一种复杂的异质性疾病，其特征为肺细胞异常生长和增殖。它是全球癌症相关死亡的主要原因，约占所有癌症死亡人数的18%。近年来，靶向治疗已成为一种有前景的肺癌治疗方法，该方法涉及使用药物选择性地靶向对癌细胞生长和存活至关重要的特定分子或信号通路。液-液相分离（LLPS）是一种基本的生物学过程，当蛋白质和其他生物分子在细胞内分离成不同的液相时就会发生。LLPS对各种细胞功能至关重要，包括无膜细胞器的形成、基因表达的调控以及对压力和其他刺激的反应。最近的研究表明，LLPS在肺癌的靶向治疗中起着关键作用，包括致癌蛋白的隔离以及基于LLPS的药物递送系统的开发。了解这些过程中LLPS的机制可为克服肺癌细胞耐药性的新治疗策略提供见解。
