Rogers P L, Jeon Y J, Lee K J, Lawford H G
School of Biotechnology and Biomolecular Sciences, UNSW, 2052 Sydney, Australia.
Adv Biochem Eng Biotechnol. 2007;108:263-88. doi: 10.1007/10_2007_060.
High oil prices, increasing focus on renewable carbohydrate-based feedstocks for fuels and chemicals, and the recent publication of its genome sequence, have provided continuing stimulus for studies on Zymomonas mobilis. However, despite its apparent advantages of higher yields and faster specific rates when compared to yeasts, no commercial scale fermentations currently exist which use Z. mobilis for the manufacture of fuel ethanol. This may change with the recent announcement of a Dupont/Broin partnership to develop a process for conversion of lignocellulosic residues, such as corn stover, to fuel ethanol using recombinant strains of Z. mobilis. The research leading to the construction of these strains, and their fermentation characteristics, are described in the present review. The review also addresses opportunities offered by Z. mobilis for higher value products through its metabolic engineering and use of specific high activity enzymes.
高油价、对用于燃料和化学品的可再生碳水化合物基原料的日益关注，以及最近其基因组序列的公布，持续推动了对运动发酵单胞菌的研究。然而，尽管与酵母相比，它具有明显的产量更高和比速率更快的优势，但目前尚无使用运动发酵单胞菌生产燃料乙醇的商业规模发酵。随着杜邦公司与布罗因公司最近宣布建立合作伙伴关系，开发一种利用运动发酵单胞菌重组菌株将木质纤维素残渣（如玉米秸秆）转化为燃料乙醇的工艺，这种情况可能会改变。本综述描述了构建这些菌株的研究及其发酵特性。该综述还探讨了运动发酵单胞菌通过代谢工程和使用特定的高活性酶生产高附加值产品的机会。
