Adam Alexander C, Grohé Christian, Stier Sebastian, Gattenlöhner Stefan, Balta Zeynep, Büttner Reinhard, Gütgemann Ines
Department of Pathology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Virchows Arch. 2007 Jul;451(1):101-4. doi: 10.1007/s00428-007-0429-0. Epub 2007 May 24.
Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin's lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.
