Aziz Luaay, Ebenfelt Anders
Department of Otorhinolaryngology, Head and Neck Surgery, Sahlgrenska University Hospital, 413 45, Göteborg, Sweden.
Clin Oral Investig. 2007 Sep;11(3):293-6. doi: 10.1007/s00784-007-0119-y. Epub 2007 May 24.
Mucositis in the oral cavity is a serious complication during radiation therapy for head and neck cancer, causing local discomfort and pain. In severe cases, hospitalization and interruption of radiotherapy may be necessary. The pathogenesis of this mucositis is not clear. With the purpose of getting more understanding of the pathogenesis of the mucositis, we examined the mucosal secretion from ten patients during radiotherapy with an imprint technique. In the secretion we studied the cellular composition and cellular function. In eight of ten treated patients the numbers of granulocytes increased in the secretion after 2 weeks of radiation therapy. The granulocytes, however, did not show any signs of phagocytosis. The patients all developed mucositis. We propose that the granulocytes in the secretion might play an important role in the development of mucositis during radiotherapy.
口腔黏膜炎是头颈部癌症放射治疗期间的一种严重并发症，会导致局部不适和疼痛。在严重的情况下，可能需要住院治疗并中断放射治疗。这种黏膜炎的发病机制尚不清楚。为了更深入了解黏膜炎的发病机制，我们采用印迹技术检查了10例放疗患者的黏膜分泌物。在分泌物中，我们研究了细胞组成和细胞功能。在10例接受治疗的患者中，有8例在放疗2周后分泌物中的粒细胞数量增加。然而，这些粒细胞没有表现出任何吞噬迹象。所有患者均发生了黏膜炎。我们认为，分泌物中的粒细胞可能在放疗期间黏膜炎的发生中起重要作用。
