Hannig M, Dounis E, Henning T, Apitz N, Stösser L
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, 66421 Homburg/Saar, Germany.
Clin Oral Investig. 2006 Mar;10(1):61-5. doi: 10.1007/s00784-005-0026-z. Epub 2006 Feb 1.
The purpose of this study was to compare the relative amount of low molecular weight salivary proteins in patients with head and neck tumours treated with radiotherapy and healthy subjects. Reverse-phase high-pressure liquid chromatography was used for protein separation. Nine protein fractions (including acidic and basic proline-rich proteins (PRPs), cystatins, histatins and statherin) were identified in saliva from irradiated patients as well as healthy subjects. However, compared with non-irradiated healthy subjects, the fraction of acidic PRPs was significantly reduced in irradiated patients. These data indicate an alteration of the relative amount of low molecular weight salivary proteins in irradiated patients besides the reduction of salivary flow.
本研究的目的是比较接受放射治疗的头颈部肿瘤患者与健康受试者中低分子量唾液蛋白的相对含量。采用反相高效液相色谱法进行蛋白质分离。在接受照射患者以及健康受试者的唾液中鉴定出9种蛋白质组分（包括酸性和碱性富含脯氨酸蛋白（PRP）、胱抑素、组蛋白和磷蛋白）。然而，与未接受照射的健康受试者相比，接受照射患者中酸性PRP的组分显著减少。这些数据表明，除唾液流量减少外，接受照射患者中低分子量唾液蛋白的相对含量也发生了改变。
