Baker D G
Arch Otolaryngol. 1982 Jan;108(1):21-4. doi: 10.1001/archotol.1982.00790490023005.
The radiobiological basis for the response of tissues in the oral cavity following therapeutic doses of ionizing radiation has been reviewed. Clinical manifestations of radiation response occur when the functional compartment of the tissue, the parenchymal cells, is depleted to some minimal value. The time course and severity of the response depend on the sensitivity of cellular compartments, the vegetative intermitotic compartment being the most sensitive and the fixed postmitotic cells being the least sensitive. Early responses are therefore seen in rapid cell renewal systems while the chronic effects are closely correlated with damage to the terminal vascular bed, a multipotential connective tissue compartment. Osteonecrosis of bone following irradiation involves a series of events, including a decreased salivary gland function, devitalization of bone, and infection. Carcinogenesis in oral cavity tissues is a very rare late sequela of therapeutic radiation.
对治疗剂量电离辐射后口腔组织反应的放射生物学基础进行了综述。当组织的功能区室即实质细胞减少到某个最小值时，就会出现辐射反应的临床表现。反应的时间进程和严重程度取决于细胞区室的敏感性，其中增殖性中间分裂细胞区室最敏感，固定的有丝分裂后细胞最不敏感。因此，在快速细胞更新系统中可观察到早期反应，而慢性效应与终末血管床（一种多能结缔组织区室）的损伤密切相关。照射后骨坏死涉及一系列事件，包括唾液腺功能下降、骨失活和感染。口腔组织发生癌变是治疗性放疗非常罕见的晚期后遗症。
