Norman Paul E, Davis Timothy M E, Le Max Tan Quoc, Golledge Jonathan
School of Surgery and Pathology, University of Western Australia, Fremantle, Western Australia.
Connect Tissue Res. 2007;48(3):125-31. doi: 10.1080/03008200701331524.
Several case-control studies have shown a significant negative association between diabetes and abdominal aortic aneurysm (AAA). This interaction has the potential to further our understanding of these two diseases but has attracted little research. The changes seen in the walls of aneurysmal aortas include inflammation and the activation of proteolytic pathways resulting in loss of elastin and other structural proteins. In contrast, diabetes is associated with increased synthesis and reduced degradation of matrix. The deposition of advanced glycation end products also renders vascular matrix resistant to proteolysis in diabetic patients. The aim of our present minireview is to compare the changes in matrix biology seen in diabetes and AAA and to explore molecular mechanisms that may explain the negative association and identify possible therapeutic implications.
多项病例对照研究表明，糖尿病与腹主动脉瘤（AAA）之间存在显著的负相关。这种相互作用有可能加深我们对这两种疾病的理解，但目前相关研究较少。动脉瘤主动脉壁的变化包括炎症反应以及蛋白水解途径的激活，导致弹性蛋白和其他结构蛋白的丢失。相比之下，糖尿病与基质合成增加和降解减少有关。晚期糖基化终末产物的沉积也使糖尿病患者的血管基质对蛋白水解具有抗性。我们本次小型综述的目的是比较糖尿病和腹主动脉瘤中基质生物学的变化，探讨可能解释这种负相关的分子机制，并确定可能的治疗意义。
