Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011 Hunan, China.
Cardiovasc Ther. 2021 Jun 16;2021:6615400. doi: 10.1155/2021/6615400. eCollection 2021.
Abdominal aortic aneurysm (AAA) is defined as a progressive segmental dilation of the abdominal aorta and is associated with high mortality. The characterized features of AAA indicate several underlying mechanisms of AAA formation and progression, including reactive oxygen species production, inflammation, and atherosclerosis. Mitochondrial functions are critical for determining cell fate, and mitochondrial dynamics, especially selective mitochondrial autophagy, which is termed as mitophagy, has emerged as an important player in the pathogenesis of several cardiovascular diseases. The PARKIN/PARIS/PGC1 pathway is associated with AAA formation and has been proposed to play a role in mitochondrial dynamics mediated by the PINK/PARKIN pathway in the pathogenesis underlying AAA. This review is aimed at deepening our understanding of AAA formation and progression, which is vital for the development of potential medical therapies for AAA.
腹主动脉瘤 (AAA) 被定义为腹主动脉的进行性节段性扩张，与高死亡率相关。AAA 的特征性表现表明 AAA 形成和进展的几个潜在机制，包括活性氧物质的产生、炎症和动脉粥样硬化。线粒体功能对于确定细胞命运至关重要，线粒体动力学，特别是选择性线粒体自噬，被称为自噬，已成为几种心血管疾病发病机制中的一个重要参与者。PARKIN/PARIS/PGC1 通路与 AAA 的形成有关，并被提出在 AAA 发病机制中通过 PINK/PARKIN 通路发挥作用，调节线粒体动力学。本综述旨在加深我们对 AAA 形成和进展的理解，这对于开发 AAA 的潜在医学疗法至关重要。
