[西西伯利亚风疹的临床与免疫学特征]
[Clinical and immunological characteristics of rubella in western Siberia].
作者信息
Malkova E M, Petrova I D, Smerdova M A, Obert A S, Pomogaeva A P, Minakova Iu V, Iur'ev S Iu, Krasnov A V, Khokhlova Z A, Golubina E A, Zinov'eva L I, Krasman O M, Ustinova E N, Tiunnikov G I, Iashina L N, Netesov S V, Petrov V S
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 2007 Mar-Apr(2):44-8.
Evaluations of immune system of 155 patients with rubella and 90 contacts with patients were examined. Detection of viral genetic material in blood, urine, and nasopharyngeal swabs has been performed using RT-PCR method. Clinical diagnosis has been confirmed by RT-PCR in 114 (73.5%) patients. Changes of laboratory tests for rubella without clinical signs of the infection were observed in 20% of contacts. Complex ELISA- and PCR-assisted examination of patients can help to determine the stage of disease and characteristics of immune response. For differential diagnostic of rubella and other infectious diseases with exanthema it is rational to perform complex examination of patients using immunologic and molecular biologic methods.
对155例风疹患者及90例与患者有接触者的免疫系统进行了评估。采用逆转录聚合酶链反应（RT-PCR）方法检测血液、尿液和鼻咽拭子中的病毒遗传物质。通过RT-PCR确诊了114例（73.5%）患者的临床诊断。在20%的接触者中观察到无感染临床症状的风疹实验室检查变化。对患者进行酶联免疫吸附测定（ELISA）和PCR联合辅助检查有助于确定疾病阶段和免疫反应特征。对于风疹与其他出疹性传染病的鉴别诊断，采用免疫和分子生物学方法对患者进行综合检查是合理的。
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