Krupitsky Evgeny M, Burakov Andrei M, Dunaevsky Igor V, Romanova Tatyana N, Slavina Tatyana Y, Grinenko Alexander Y
Research Laboratory, St. Petersburg Regional Center of Addictions and Psychopharmacology, St. Petersburg State Pavlov Medical University, St. Petersburg, Russia.
J Psychoactive Drugs. 2007 Mar;39(1):13-9. doi: 10.1080/02791072.2007.10399860.
A prior study found that one ketamine-assisted psychotherapy session was significantly more effective than active placebo in promoting abstinence (Krupitsky et al. 2002). In this study of the efficacy of single versus repeated sessions of ketamine-assisted psychotherapy in promoting abstinence in people with heroin dependence, 59 detoxified inpatients with heroin dependence received a ketamine-assisted psychotherapy (KPT) session prior to their discharge from an addiction treatment hospital, and were then randomized into two treatment groups. Participants in the first group received two addiction counseling sessions followed by two KPT sessions, with sessions scheduled on a monthly interval (multiple KPT group). Participants in the second group received two addiction counseling sessions on a monthly interval, but no additional ketamine therapy sessions (single KPT group). At one-year follow-up, survival analysis demonstrated a significantly higher rate of abstinence in the multiple KPT group. Thirteen out of 26 subjects (50%) in the multiple KPT group remained abstinent, compared to 6 out of 27 subjects (22.2%) in the single KPT group (p < 0.05). No differences between groups were found in depression, anxiety, craving for heroin, or their understanding of the meaning of their lives. It was concluded that three sessions of ketamine-assisted psychotherapy are more effective than a single session for the treatment of heroin addiction.
先前的一项研究发现，在促进戒毒方面，一次氯胺酮辅助心理治疗疗程比活性安慰剂显著更有效（Krupitsky等人，2002年）。在这项关于单次与重复氯胺酮辅助心理治疗疗程对海洛因依赖者促进戒毒效果的研究中，59名已戒毒的海洛因依赖住院患者在从戒毒治疗医院出院前接受了一次氯胺酮辅助心理治疗（KPT）疗程，然后被随机分为两个治疗组。第一组参与者接受两次成瘾咨询疗程，随后是两次KPT疗程，疗程安排为每月一次（多次KPT组）。第二组参与者每月接受两次成瘾咨询疗程，但不再接受额外的氯胺酮治疗疗程（单次KPT组）。在一年的随访中，生存分析表明多次KPT组的戒毒率显著更高。多次KPT组的26名受试者中有13名（50%）保持戒毒状态，而单次KPT组的27名受试者中有6名（22.2%）保持戒毒状态（p<0.05）。在抑郁、焦虑、对海洛因的渴望或他们对生活意义的理解方面，两组之间未发现差异。研究得出结论，三次氯胺酮辅助心理治疗疗程在治疗海洛因成瘾方面比单次疗程更有效。
