Robaszkiewicz M, Volant A, Guez C, Benzenou A, Gouerou H
Service d'Hépato-Gastroentérologie, CHU Morvan, Brest.
Gastroenterol Clin Biol. 1991;15(8-9):644-7.
The authors report two cases of esophageal polypoid pseudosarcoma with favorable outcome after endoscopic and medical treatment. Neither of the two patients could undergo general anesthesia. Endoscopic resection or monopolar electrocoagulation of the tumor was associated with chemotherapy and radiation therapy. A complete response of the tumor was observed in both cases. The two patients were alive and well with no evidence of recurrence or metastasis 3 and 5 years after diagnosis. Immunohistochemical study of those two tumors with monoclonal antibodies to intermediate filaments (keratin and vimentin) suggests duality in the spindle cell component. It may explain the biological behaviour of these particular cancers that have a better prognosis than other types of squamous cell carcinomas of the esophagus.
作者报告了两例食管息肉样假肉瘤病例，经内镜及药物治疗后预后良好。两名患者均无法接受全身麻醉。肿瘤的内镜切除或单极电凝联合化疗及放疗。两例均观察到肿瘤完全缓解。两名患者在诊断后3年和5年存活良好，无复发或转移迹象。用针对中间丝（角蛋白和波形蛋白）的单克隆抗体对这两个肿瘤进行免疫组化研究，提示梭形细胞成分具有双重性。这可能解释了这些特殊癌症的生物学行为，其预后比其他类型的食管鳞状细胞癌更好。
