SubAcute Unit, Geriatric Medicine, Greater Baltimore Medical Center, Baltimore, Maryland, USAJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Clin Drug Investig. 2005;25(4):219-30. doi: 10.2165/00044011-200525040-00001.
Quality of life (QOL), sexuality in particular, has become an important consideration in treatment decisions for men with lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). To determine the impact of these conditions on sexual function and QOL in older men, this article provides a review of clinical data on the relationship between sexual dysfunction and symptom severity, effective clinical assessment, treatment options, and the influence of current therapies on sexual function and QOL. The various symptoms of BPH can adversely affect sexual functioning and therefore QOL. Moreover, there may be a direct association between symptom severity and sexual dysfunction that may affect QOL.Patients base their decisions regarding treatment choices for BPH more on anticipated relief of lower urinary tract symptoms and improved QOL (including sexual functioning) than on improvements in physical measures. Although medications and surgery may relieve LUTS, sexual dysfunction is a common adverse result. Newer pharmacological interventions such as specific alpha-adrenergic blocking agents like tamsulosin may help improve sexual function and QOL in men with symptomatic BPH.
生活质量（QOL），尤其是性功能，已成为治疗与良性前列腺增生（BPH）相关下尿路症状（LUTS）男性的重要考虑因素。为了确定这些情况对老年男性性功能和生活质量的影响，本文综述了性功能障碍与症状严重程度、有效临床评估、治疗选择以及当前治疗方法对性功能和生活质量影响之间关系的临床数据。BPH 的各种症状会对性功能产生不利影响，从而影响生活质量。此外，症状严重程度与性功能障碍之间可能存在直接关联，从而影响生活质量。患者在选择 BPH 治疗方案时，更多地基于对下尿路症状缓解和生活质量（包括性功能）改善的预期，而不是基于身体指标的改善。尽管药物治疗和手术可以缓解 LUTS，但性功能障碍是常见的不良后果。新型药物干预措施，如特定的α肾上腺素能阻滞剂（如坦索罗辛），可能有助于改善有症状的 BPH 男性的性功能和生活质量。
