Liatsikos E N, Katsakiori P F, Assimakopoulos K, Voudoukis T, Kallidonis P, Constantinides C, Athanasopoulos A, Stolzenburg Jens-Uwe, Perimenis P
Department of Urology, University of Patras, School of Medicine, Patras, Greece.
J Endourol. 2007 May;21(5):538-41. doi: 10.1089/end.2006.0107.
To evaluate the efficacy of doxazosin in inducing spontaneous passage of stones in the distal ureter and to compare its efficacy according to the size of the stone.
Seventy-three patients with a mean age of 46.38 +/- 10.17 years who presented with a distal-ureteral stone were divided into four groups according to stone size and drug treatment: <5 mm without doxazosin (group A; n=15); 5-10 mm (group B; n=16); <5 mm with doxazosin 4 mg/day for 4 weeks (group C; n=20); and 5-10 mm with doxazosin 4 mg/day for 4 weeks (group D; n=22). Groups A and B served as controls for groups C and D, respectively.
Spontaneous stone passage was documented in 9 patients (60%) in group A v 17 (85%) in group C (P=0.047) and 7 (43.75%) in group B v 16 (72.73%) in group D (P=0.036). The average expulsion time was 8.78 +/- 1.09 days in group A v 7.59 +/- 0.80 days in group C (P=0.004) and 12.14 +/- 1.35 days in group B v 7.06 +/- 1.29 days in group D (P<0.0001). The number of pain episodes in group D patients was significantly lower than in group B (P +/- 0.0078).
Doxazosin treatment proved to be safe and effective for distal-ureteral stones, as determined by earlier expulsion, decreased colic frequency, and absence of side effects. The efficacy of doxazosin was significantly higher for 5-to 10-mm stones than for smaller ones.
评估多沙唑嗪促使输尿管下段结石自然排出的疗效，并根据结石大小比较其疗效。
73例平均年龄为46.38±10.17岁的输尿管下段结石患者，根据结石大小和药物治疗分为四组：结石<5 mm且未使用多沙唑嗪（A组；n = 15）；结石5 - 10 mm（B组；n = 16）；结石<5 mm且服用多沙唑嗪4 mg/天，共4周（C组；n = 20）；结石5 - 10 mm且服用多沙唑嗪4 mg/天，共4周（D组；n = 22）。A组和B组分别作为C组和D组的对照。
A组9例（60%）结石自然排出，C组为17例（85%）（P = 0.047）；B组7例（43.75%）结石自然排出，D组为16例（72.73%）（P = 0.036）。A组平均排出时间为8.78±1.09天，C组为7.59±0.80天（P = 0.004）；B组平均排出时间为12.14±1.35天，D组为7.06±1.29天（P<0.0001）。D组患者疼痛发作次数明显低于B组（P = 0.0078）。
多沙唑嗪治疗输尿管下段结石安全有效，表现为排出时间更早、绞痛频率降低且无副作用。多沙唑嗪对5 - 10 mm结石的疗效明显高于较小结石。
