Department of Urology, Kecioren Training and Research Hospital, Kardesler Koop. 182.cad, 175. Sok., No:14/8, 06010 Etlik, Ankara, Turkey.
Int Urol Nephrol. 2011 Sep;43(3):645-9. doi: 10.1007/s11255-010-9867-8. Epub 2010 Nov 12.
To evaluate the effectiveness of doxazosin on the rate of spontaneous passage of distal ureteral stones in female patients.
A total of 80 patients with stones sized 10 mm or smaller, located in the distal part of the ureter, were included. They were divided into two groups, according to the gender. Patients were followed-up until passage of the stone or for a maximum of 3 weeks. The number of pain episodes, stone expulsion rate and time, and possible side effects of medications were recorded and compared in both groups.
All patients completed the study. No statistically significant difference was observed regarding patient age, stone size, and stone location between the groups (P > 0.05). Stone expulsion occurred in 29 patients (72.5%) in group 1 and in 28 patients (70%) in group 2 (P = 0.35). Mean time to expulsion was 6.5 days (range 3-15 days) in the male arm and 7.5 days (range 4-17 days) in the female arm (P = 0.97). There were no differences between the groups in the number of colic episodes and analgesic use.
Medical treatment of distal ureteral stones with doxazosin has similar stone passage rate, expulsion time, and safety in women compared with men.
评估多沙唑嗪对女性患者远端输尿管结石自行排出率的疗效。
共纳入 80 例结石大小为 10mm 或以下、位于输尿管远端的患者。根据性别将他们分为两组。对患者进行随访，直至结石排出或最长 3 周。记录并比较两组患者的疼痛发作次数、结石排出率和时间以及药物可能出现的副作用。
所有患者均完成了研究。两组患者的年龄、结石大小和结石位置无统计学差异（P＞0.05）。第 1 组 29 例（72.5%）患者和第 2 组 28 例（70%）患者结石排出（P=0.35）。男性组结石排出的平均时间为 6.5 天（范围 3-15 天），女性组为 7.5 天（范围 4-17 天）（P=0.97）。两组绞痛发作次数和镇痛药使用无差异。
与男性相比，女性接受多沙唑嗪治疗远端输尿管结石的排石率、排石时间和安全性相似。
