Foltzer C, Strosser M T, Harvey S, Mialhe P
J Endocrinol. 1985 Jul;106(1):21-5. doi: 10.1677/joe.0.1060021.
The effects of plasma free fatty acids (FFA) and somatostatin-14 (S-14) on concentrations of plasma GH, glucagon and insulin were investigated in juvenile ducks. Oleic acid, S-14 or both were infused into 4- to 7-week-old birds and plasma GH, glucagon-like immunoreactivity (GLI), immunoreactive insulin (IRI) and FFA were measured. An increase in plasma GH and a decrease in GLI but no change in IRI was observed after infusion of 9 mg oleic acid/kg per min. A decrease in plasma GH, FFA and IRI and an increase in plasma GLI was seen after infusion of 800 ng S-14/kg per min. These effects of S-14 on IRI and GLI were abolished when S-14 was infused simultaneously with oleic acid. It is concluded that FFA have a direct stimulatory effect on GH secretion and an inhibitory effect on glucagon secretion. Somatostatin-14 directly inhibits the secretion of GH and its stimulatory effect on the secretion of glucagon is mediated by a depression in concentrations of plasma FFA. Finally, S-14 has no effect on plasma insulin when basal levels of plasma FFA are maintained.
在幼鸭中研究了血浆游离脂肪酸（FFA）和生长抑素-14（S-14）对血浆生长激素（GH）、胰高血糖素和胰岛素浓度的影响。将油酸、S-14或两者注入4至7周龄的幼鸭体内，并测定血浆GH、胰高血糖素样免疫反应性（GLI）、免疫反应性胰岛素（IRI）和FFA。以每分钟9毫克油酸/千克的速度注入后，观察到血浆GH升高，GLI降低，但IRI无变化。以每分钟800纳克S-14/千克的速度注入后，血浆GH、FFA和IRI降低，血浆GLI升高。当S-14与油酸同时注入时，S-14对IRI和GLI的这些作用被消除。得出的结论是，FFA对GH分泌有直接刺激作用，对胰高血糖素分泌有抑制作用。生长抑素-14直接抑制GH分泌，其对胰高血糖素分泌的刺激作用是由血浆FFA浓度降低介导的。最后，当维持血浆FFA的基础水平时，S-14对血浆胰岛素无影响。
