Chang Cheng-Shyong, Chang Julia H, Hsu Nicholas C, Lin Hsuan-Yu, Chung Chih-Yuan
Division of Hematology-Oncology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
BMC Cancer. 2007 May 24;7:88. doi: 10.1186/1471-2407-7-88.
B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of infiltrating lymphocytes and dendritic cells to assess their significance in patients with nasopharyngeal carcinoma (NPC).
Expression of CD80, CD86, HLA-DR, S-100 protein and the presence of infiltrating lymphocytes and follicular dendritic reticulum cells were immunohistochemically examined on the paraffin-embedded tissue blocks from newly diagnosed NPC patients (n = 50). The results were correlated with clinical outcome of patients.
CD80 and CD86 were each expressed in 10 of 50 cases in which they co-expressed in 9 cases. Univariate analysis revealed that patients with CD80/CD86 expression had significantly better overall survival than those without it (P = 0.017), but after adjustment for stage, nodal status, and treatment, the expression of CD80/CD86 did not significantly correlate with overall survival. Expression of HLA-DR and the presence of infiltrating lymphocytes and dendritic cells did not appear to have impact on the survival of patients.
Expression of CD80 and CD86 costimulatory molecules appears to be a marker of better survival in patient with NPC.
B7共刺激信号对于在识别肿瘤抗原后触发T细胞活化至关重要。本研究检测了共刺激分子B7-1（CD80）和B7-2（CD86）以及HLA-DR的表达情况，同时检测了浸润淋巴细胞和树突状细胞的存在情况，以评估它们在鼻咽癌（NPC）患者中的意义。
对新诊断的NPC患者（n = 50）石蜡包埋组织块进行免疫组织化学检测，检测CD80、CD86、HLA-DR、S-100蛋白的表达以及浸润淋巴细胞和滤泡性树突状网状细胞的存在情况。将结果与患者的临床结局相关联。
50例中有10例表达CD80，10例表达CD86，其中9例同时表达。单因素分析显示，表达CD80/CD86的患者总生存期明显优于未表达者（P = 0.017），但在调整分期、淋巴结状态和治疗后，CD80/CD86的表达与总生存期无显著相关性。HLA-DR的表达以及浸润淋巴细胞和树突状细胞的存在似乎对患者的生存无影响。
共刺激分子CD80和CD86的表达似乎是NPC患者生存期较好的一个标志物。
