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晚期艾滋病毒诊断的相关因素:对检测政策的影响。

Correlates of late HIV diagnosis: implications for testing policy.

作者信息

Delpierre Cyrille, Dray-Spira Rosemary, Cuzin Lise, Marchou Bruno, Massip Patrice, Lang Thierry, Lert France

机构信息

INSERM U558, F31073, Toulouse, France.

出版信息

Int J STD AIDS. 2007 May;18(5):312-7. doi: 10.1258/095646207780749709.

Abstract

To develop new strategies aimed to reduce the delay in seeking HIV diagnosis, we proposed to identify correlates of late diagnosis of HIV infection in France. Late testing was studied among the 1077 patients diagnosed from 1996 and enrolled in the ANRS-EN12-VESPA, a representative sample of the French HIV-infected population. Patients were defined as 'late testers' if they had presented either clinical AIDS events or CD4 cell count <200/mm(3) at diagnosis. In all, 33.1% were classified as late testers, among whom 42.6% had discovered their HIV infection at the time of AIDS events. This proportion increased with age and was higher for heterosexual men and migrants. Among the non-migrants heterosexual population, late diagnosis was more frequent among people in longstanding couple, with children and conversely was less likely among individuals with large number of sexual partners. Being on welfare benefit before diagnosis was associated with a lower risk of late diagnosis. Among migrants, lack of recent steady partnership was associated with an increased risk, as being diagnosed during the first year of stay in France. Our results showed low risk factors of infection were risk factors of late testing. Public communication should aim at improving the awareness of HIV risk in longstanding couples with stable employment, both among homosexual and heterosexual populations. Among migrants, HIV testing with informed consent short after entry should be improved, especially towards individuals not in couple.

摘要

为制定旨在减少寻求HIV诊断延迟的新策略,我们提议确定法国HIV感染延迟诊断的相关因素。对1996年诊断出并纳入ANRS-EN12-VESPA(法国HIV感染人群的代表性样本)的1077例患者进行了晚期检测研究。如果患者在诊断时出现临床艾滋病事件或CD4细胞计数<200/mm³,则被定义为“晚期检测者”。总体而言,33.1%被归类为晚期检测者,其中42.6%在艾滋病事件发生时发现自己感染了HIV。这一比例随年龄增长而增加,在异性恋男性和移民中更高。在非移民异性恋人群中,长期伴侣且有孩子的人晚期诊断更为常见,相反,性伴侣数量多的人晚期诊断的可能性较小。诊断前领取福利与晚期诊断风险较低相关。在移民中,缺乏近期稳定伴侣关系与风险增加相关,如同在法国停留的第一年被诊断出。我们的结果表明,低感染风险因素是晚期检测的风险因素。公共宣传应旨在提高同性恋和异性恋人群中就业稳定的长期伴侣对HIV风险的认识。对于移民,应改进入境后不久在知情同意下进行的HIV检测,特别是针对非伴侣关系的个体。

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