胸主动脉粥样硬化负荷指数可预测接受经食管超声心动图检查患者的冠状动脉疾病。
Thoracic aorta atherosclerosis burden index predicts coronary artery disease in patients undergoing transesophageal echocardiography.
作者信息
Frogoudaki Alexandra, Barbetseas John, Aggeli Constadina, Panagiotakos Demosthenes, Lambrou Spyros, Pitsavos Christos, Stefanadis Christodoulos
机构信息
Thriasion General Hospital, Magoula, Greece.
出版信息
Atherosclerosis. 2008 Mar;197(1):232-6. doi: 10.1016/j.atherosclerosis.2007.03.041. Epub 2007 May 23.
AIMS
The severity of thoracic aortic atherosclerosis (TAA) is associated with the extent of coronary artery disease (CAD). The aim of this study is to quantitative this relationship by developing a novel atherosclerotic index.
METHODS AND RESULTS
Two hundred and forty six consecutive patients underwent transesophageal echocardiography (TEE) and coronary angiography. A grading system was used to define the extent of TAA for individual segment of the thoracic aorta. TAA burden index (TAABI) was defined as the sum of the grading for each segment. Of the derived values TAABI had the greatest specificity and sensitivity in predicting CAD. A TAABI of greater than 6 was associated with 16-fold increase in the probability of CAD with a specificity of 88% and a sensitivity of 81%. The positive predictive value was 77% and the negative predictive value 90%.
CONCLUSION
A TAABI value of greater than 6 accurately predicts the presence of CAD. Patients with no or mild TAA are at low risk of having angiographically significant CAD.
目的
胸主动脉粥样硬化（TAA）的严重程度与冠状动脉疾病（CAD）的范围相关。本研究的目的是通过开发一种新的动脉粥样硬化指数来量化这种关系。
方法与结果
连续246例患者接受了经食管超声心动图（TEE）和冠状动脉造影。采用分级系统来定义胸主动脉各节段的TAA范围。TAA负荷指数（TAABI）定义为各节段分级的总和。在得出的各项数值中，TAABI在预测CAD方面具有最高的特异性和敏感性。TAABI大于6与CAD发生概率增加16倍相关，特异性为88%，敏感性为81%。阳性预测值为77%，阴性预测值为90%。
结论
TAABI值大于6可准确预测CAD的存在。无TAA或轻度TAA的患者发生血管造影显示显著CAD的风险较低。
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