Ruiz Pedro J Garcia, Bernardos Vicenta Sanchez, Bartolomé Manuel, Torres Araceli García
Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain.
J Neurol Sci. 2007 Sep 15;260(1-2):283-5. doi: 10.1016/j.jns.2007.04.034. Epub 2007 May 23.
Slowing of motor performance in human aging is a well demonstrated clinical observation. Age-related motor decline has been also confirmed in animal models including rodents and non human primates. We studied the motor performance of 60 normal subjects (age: 20-87). Motor study included the four timed tests (TT) recommended in CAPIT protocol: pronation-supination (PS), finger dexterity (FD), movement between two points (MTP) or tapping, and walking test (WT). Finally we compared normal controls with a group of 30 patients with Parkinson's disease (PD) of similar age. Age inversely correlated with TT performance in normal subjects (for PS, r:0.33, p<0.01; FD, r:0.44, p<0.0005; MTP, r:0.51, p<0.0001; WT, r:0.59, p<0.0001, Pearson). Our results confirm that motor performance (measured with CAPIT TT) deteriorates linearly with age. Simple tasks, such as CAPIT TT can help to study and quantify age-related motor decline.
人类衰老过程中运动表现的减缓是一项已得到充分证实的临床观察结果。在包括啮齿动物和非人类灵长类动物在内的动物模型中，与年龄相关的运动能力下降也得到了证实。我们研究了60名正常受试者（年龄：20 - 87岁）的运动表现。运动研究包括CAPIT方案中推荐的四项定时测试（TT）：旋前 - 旋后（PS）、手指灵活性（FD）、两点间移动（MTP）或敲击以及步行测试（WT）。最后，我们将正常对照组与一组年龄相仿的30名帕金森病（PD）患者进行了比较。在正常受试者中，年龄与TT表现呈负相关（对于PS，r：0.33，p < 0.01；FD，r：0.44，p < 0.0005；MTP，r：0.51，p < 0.0001；WT，r：0.59，p < 0.0001，Pearson相关性分析）。我们的结果证实，运动表现（用CAPIT TT测量）随年龄呈线性下降。像CAPIT TT这样的简单任务有助于研究和量化与年龄相关的运动能力下降。
