García-Ruiz P J, Sánchez-Bernardos V, Cabo-López I
Unidad de Trastornos del Movimiento, Servicio de Neurología, Fundación Jiménez Díaz y CIBERNED, Madrid, España.
Rev Neurol. 2009;48(12):617-9.
At present, the evaluation of Parkinson's disease (PD) relies on clinical scales, mainly Unified Parkinson's Disease Rating Scale (UPDRS); however, other objective methods have been considered including timed tests.
We studied the motor performance of 53 patients with PD (34 male, 19 female; age 61.9 +/- 8.9 years; age at onset 51.9 +/- 11 years, clinical stage: 2.6 +/- 0.73). Motor evaluation comprised UPDRS and CAPIT timed tests including pronation-supination, finger dexterity, movement between two points or tapping, and walking test. Clinical evaluation was performed in baseline conditions (twelve hours off their medication) and in their best on state, after a standard dose of 200 mg of levodopa.
All CAPIT timed tests, especially tapping, maintained an excellent correlation with UPDRS in both off and on state. Tapping seems to be the best CAPIT timed test for objective motor evaluation of PD.
目前,帕金森病(PD)的评估依赖于临床量表,主要是统一帕金森病评定量表(UPDRS);然而,也考虑了其他客观方法,包括定时测试。
我们研究了53例帕金森病患者的运动表现(男性34例,女性19例;年龄61.9±8.9岁;发病年龄51.9±11岁,临床分期:2.6±0.73)。运动评估包括UPDRS和CAPIT定时测试,后者包括旋前-旋后、手指灵活性、两点间移动或敲击以及步行测试。临床评估在基线状态(停药12小时)和服用200mg标准剂量左旋多巴后的最佳状态下进行。
所有CAPIT定时测试,尤其是敲击测试,在停药和服药状态下与UPDRS均保持极好的相关性。敲击测试似乎是用于帕金森病客观运动评估的最佳CAPIT定时测试。