Garcia Ruiz Pedro J, Sanchez Bernardos Vicenta
Department of Neurology, Fundacion Jimenez Díaz, Avda Reyes Catolicos 2, Madrid 28040, Spain.
J Neurol Sci. 2008 Jul 15;270(1-2):67-9. doi: 10.1016/j.jns.2008.02.002. Epub 2008 Mar 5.
At present, the evaluation of Parkinson's Disease (PD) relies mainly on Unified Parkinson's Disease Rating Scale (UPDRS). Other objective measures have been proposed, including functional studies, timed tests and ambulatory activity monitors (AAM). We carried out a prospective study to analyze the utility and correlation of the AAM: ActiTrac with UPDRS scores and timed tests in patients with PD. We studied 28 patients with idiopathic PD (age: 62 +/- 11 years; duration of illness: 7.7 +/- 4.4 years; clinical stage 2.3 +/- 0.39). Motor evaluation included UPDRS and five timed tests: Purdue Pegboard test and those proposed in CAPIT protocol, pronation-supination (PS), finger dexterity (FD), movement between two points (MTP) and walking test (WT). Clinical evaluation was performed in off condition, at 9 a.m., (12h off their medication). Finally, ActiTrac was placed on the wrist (more affected side) continuously for at least 72h. ActiTrac activity was correlated (Spearman) with total UPDRS (r: - 0.53, p < 0.005) and motor UPDRS (r:- 0.46, p: 0.01); UPDRS rigidity subscore (r:- 0.52, p < 0.01); UPDRS bradykinesia subscore (r:- 0.48; p:0.01); FD (r: - 0.47 p: 0.01), WT (r: - 0.49, p < 0.01) and Purdue test (r:0.54; p < 0.01). ActiTrac seems to be a reasonably accurate method to evaluate motor activity in PD.
目前，帕金森病（PD）的评估主要依赖统一帕金森病评定量表（UPDRS）。也有人提出了其他客观测量方法，包括功能研究、定时测试和动态活动监测仪（AAM）。我们进行了一项前瞻性研究，以分析AAM：ActiTrac在帕金森病患者中的效用及其与UPDRS评分和定时测试的相关性。我们研究了28例特发性帕金森病患者（年龄：62±11岁；病程：7.7±4.4年；临床分期2.3±0.39）。运动评估包括UPDRS和五项定时测试：普渡钉板测试以及CAPIT方案中提出的测试、旋前-旋后（PS）、手指灵活性（FD）、两点间移动（MTP）和步行测试（WT）。临床评估在上午9点“关期”（停药12小时后）进行。最后，将ActiTrac连续放置在手腕（受影响较重的一侧）上至少72小时。ActiTrac活动与UPDRS总分（r：-0.53，p<0.005）和运动UPDRS（r：-0.46，p：0.01）；UPDRS强直子评分（r：-0.52，p<0.01）；UPDRS运动迟缓子评分（r：-0.48；p：0.01）；FD（r：-0.47，p：0.01）、WT（r：-0.49，p<0.01）和普渡测试（r：0.54；p<0.01）相关。ActiTrac似乎是评估帕金森病运动活动的一种相当准确的方法。
