Tart Anne H, Walker Mark J, Musser James M
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, and Department of Pathology, The Methodist Hospital, 6565 Fannin Street B490, Houston, TX 77030, USA.
Trends Microbiol. 2007 Jul;15(7):318-25. doi: 10.1016/j.tim.2007.05.001. Epub 2007 May 23.
Group A Streptococcus (GAS) has long been recognized as a human pathogen causing an exceptionally broad range of infections. Despite intense research, however, the molecular mechanisms of GAS disease remain unclear. Recently, many important discoveries have been made that shed light on GAS pathogenesis and open exciting avenues for future research. Advances in genome sequencing, microarray technology and proteomic analysis, in combination with the development of more suitable animal models, have markedly increased our knowledge of the mechanisms underlying GAS pathogenesis. The information gained from these studies will translate into improved diagnostics and new targets for therapeutic drugs and vaccines.
A组链球菌（GAS）长期以来一直被认为是一种能引发极其广泛感染的人类病原体。然而，尽管进行了深入研究，GAS疾病的分子机制仍不清楚。最近，已经有许多重要发现，这些发现为GAS的发病机制提供了线索，并为未来的研究开辟了令人兴奋的途径。基因组测序、微阵列技术和蛋白质组分析的进展，再加上更合适的动物模型的开发，显著增加了我们对GAS发病机制基础的认识。从这些研究中获得的信息将转化为改进的诊断方法以及治疗药物和疫苗的新靶点。
