视网膜血管管径、糖尿病与视网膜病变。

Retinal vascular caliber, diabetes, and retinopathy.

作者信息

Kifley Annette, Wang Jie Jin, Cugati Sudha, Wong Tien Y, Mitchell Paul

机构信息

Centre for Vision Research, Department of Ophthalmology, University of Sydney, Australia.

出版信息

Am J Ophthalmol. 2007 Jun;143(6):1024-6. doi: 10.1016/j.ajo.2007.01.034.

DOI:10.1016/j.ajo.2007.01.034

PMID:17524767

Abstract

PURPOSE

To assess the relationship of retinal vessel caliber with diabetes and diabetic retinopathy (DR).

DESIGN

Population-based cross-sectional analysis of the Blue Mountains Eye Study, Australia (n = 3,654, age >or=49 years).

METHODS

Diabetes was defined as physician-diagnosed or fasting blood glucose >or= 7.0 mmol/l; impaired fasting glucose as fasting glucose 6.1 to 6.9 mmol/l. DR was graded from retinal photographs. Retinal vessel caliber was measured from digitized images.

RESULTS

After controlling for age, gender, blood pressure, and other factors, mean retinal venular caliber was significantly wider in participants with moderate-severe nonproliferative DR (severe 262.7 microm; moderate 236.7 microm) than in nondiabetic participants (221.9 microm) or participants with diabetes but no DR (221.2 microm) (P < .0001). Mean retinal arteriolar caliber was significantly wider in participants with diabetes (193.5 microm) than in nondiabetic participants (190.2 microm) (P < .01).

CONCLUSIONS

Increasing severity of DR in persons with diabetes is associated with widening of retinal venular caliber.

摘要

目的

评估视网膜血管管径与糖尿病及糖尿病视网膜病变（DR）之间的关系。

设计

基于人群的澳大利亚蓝山眼研究横断面分析（n = 3654，年龄≥49岁）。

方法

糖尿病定义为经医生诊断或空腹血糖≥7.0 mmol/l；空腹血糖受损定义为空腹血糖6.1至6.9 mmol/l。DR根据视网膜照片分级。视网膜血管管径通过数字化图像测量。

结果

在控制年龄、性别、血压及其他因素后，中度至重度非增殖性DR患者（重度262.7微米；中度236.7微米）的视网膜静脉平均管径显著宽于非糖尿病患者（221.9微米）或患有糖尿病但无DR的患者（221.2微米）（P <.0001）。糖尿病患者的视网膜动脉平均管径（193.5微米）显著宽于非糖尿病患者（190.2微米）（P <.01）。