Noshad H, Ardalan M R, Mortazavi M, Tayebi H, Safa J, Nezami N
Nephrology Division, Department of Internal Medicine, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran.
Transplant Proc. 2007 May;39(4):871-4. doi: 10.1016/j.transproceed.2007.04.007.
We sought to determine the prevalence of cardiovascular disease and risk factors among chronic renal failure (CRF) patients on the transplantation waiting list.
Fifty CRF patients on chronic hemodialysis who underwent evaluation for transplantation were compared with 60 hypertensive patients matched for age. We used Framingham scoring to calculate the absolute risk; relative risk was calculated based on the low-risk Framingham cohort.
According to traditional risk factors, a significant difference was observed in systolic blood pressure and total cholesterol (greater in the hypertensive group), and in the prevalence of the male gender, smoking, and diabetes, which were greater in the CRF group. The latter had a greater degree of left ventricular hypertrophy, lower diastolic blood pressure, and a lower prevalence of familial history of cardiovascular disease and obesity. Patients with CRF had a greater relative risk compared with the Framingham control population, but it did not differ from that observed in the group of hypertensive individuals.
The prevalence of cardiovascular disease and traditional risk factors is high among renal transplantation candidates. The Framingham equations do not adequately quantify the real cardiovascular risk; other risk factors specific for that population probably contribute to their greater cardiovascular risk.
我们试图确定等待移植的慢性肾衰竭（CRF）患者中心血管疾病及危险因素的患病率。
将50例接受移植评估的慢性血液透析CRF患者与60例年龄匹配的高血压患者进行比较。我们使用弗明汉评分来计算绝对风险；相对风险是基于低风险的弗明汉队列计算得出的。
根据传统危险因素，收缩压和总胆固醇存在显著差异（高血压组更高），男性、吸烟和糖尿病的患病率也有差异，CRF组更高。CRF组左心室肥厚程度更高、舒张压更低，心血管疾病家族史和肥胖的患病率更低。与弗明汉对照人群相比，CRF患者的相对风险更高，但与高血压患者组观察到的风险无差异。
肾移植候选者中心血管疾病和传统危险因素的患病率很高。弗明汉方程不能充分量化实际的心血管风险；该人群特有的其他危险因素可能导致其心血管风险更高。
