Yazdani M, Izadpanahi M H, Gharaati M R, Tadayonn F
Department of Urology and Kidney Transplant, Khorshid Hospital, Isfahan, Iran.
Transplant Proc. 2007 May;39(4):904-6. doi: 10.1016/j.transproceed.2007.03.029.
In the past, the majority of renal transplantations in Iran were from living donors, but recently cadaveric donation of organs is increasing. We reviewed our experience on kidney transplantation from cadaveric donors for the past 5 years in our center.
Between July 1998 and September 2004, 122 kidneys were removed from 61 cases of brain-dead patients and transplanted in 114 patients with end-stage renal disease in our center. Two kidneys had tumoral involvement and were discarded. Three kidneys were transplanted in other centers and three patients received en bloc kidney transplantations. In addition, we performed nine cases of heart, one case of liver, and one case of lung transplantations. All the recipients were followed for at least 1 year and posttreatment renal function and graft survival were determined.
All cadaveric donors were brain dead due to car (30%) and motocycle (70%) accidents, with ages ranging from 5 to 56 years (mean, 24/4 years). The mean warm and total cold ischemia times were 7 minutes and 8.1 hours, respectively. The mean distance between harvesting center and our hospital was 65 km. The 1-year graft survival was 92.3%, with mean serum creatinine of 1.76 +/- 0.79 at 1 year. Of other transplanted organs, the liver and lung recipients died 24 hours and 45 days after operation. Among heart recipients, four are still alive.
Cadaveric donors in developing countries including Iran can be excellent sources of organ donation.
过去，伊朗的大多数肾移植来自活体供体，但最近尸体器官捐赠呈上升趋势。我们回顾了本中心过去5年尸体供肾移植的经验。
1998年7月至2004年9月，从61例脑死亡患者身上取出122个肾脏，移植给本中心114例终末期肾病患者。两个肾脏有肿瘤累及被丢弃。三个肾脏移植到了其他中心，三名患者接受了整块肾移植。此外，我们还进行了9例心脏移植、1例肝脏移植和1例肺移植。所有受者均随访至少1年，测定治疗后肾功能和移植物存活率。
所有尸体供者均因车祸（30%）和摩托车事故（70%）导致脑死亡，年龄5至56岁（平均24.4岁）。平均热缺血时间和总冷缺血时间分别为7分钟和8.1小时。取肾中心与我院的平均距离为65公里。1年移植物存活率为92.3%，1年时平均血清肌酐为1.76±0.79。在其他移植器官中，肝脏和肺移植受者分别在术后24小时和45天死亡。在心脏移植受者中，4人仍存活。
包括伊朗在内的发展中国家的尸体供者可以成为优秀的器官捐赠来源。
