Zeyneloglu P, Pirat A, Guner M, Torgay A, Karakayali H, Arslan G
Department of Anesthesiology, Baskent University Faculty of Medicine, Ankara, Turkey.
Transplant Proc. 2007 May;39(4):1187-9. doi: 10.1016/j.transproceed.2007.02.019.
Immediate postoperative extubation may reduce the incidence of postoperative respiratory complications after orthotopic liver transplantation (OLT). We evaluated the predictors of immediate tracheal extubation in the operating room (OR) in our patients by retrospectively reviewing data from all patients who underwent OLT between January 2004 and June 2006. The patients were divided into two groups according to whether they had undergone extubation in the OR (group 1 n=52) or in the intensive care unit (ICU; group 2 n=48). When compared with the patients in group 2, those in group 1 had lower mean preoperative serum creatinine levels (0.9 +/- 1 vs 0.6 +/- 0.3 mg/dL, P=.04) and intraoperative transfusion requirements (packed red blood cells, 35.5 +/- 29.8 vs 25.6 +/- 19.0 mL/kg; P=.05, and fresh frozen plasma, 33.1 +/- 15.6 vs 25.7 +/- 14.3 mL/kg; P=.01). The incidence of intraoperative hypotension and emergent OLT was significantly greater in group 2 than group 1 (33.3% vs 13.5%, P=.01 and 45.8% vs 21.2%, respectively, P=.009). On logistic regression analysis, only emergent OLT (P=.009, odds ratio = 3.5) and intraoperative hypotension (P=.018, odds ratio = 3.7) were significantly associated with a lower probability of immediate postoperative extubation in the OR. Our results suggested that hemodynamic stability and elective OLT were predictors of successful immediate tracheal extubation in the OR.
原位肝移植(OLT)术后立即拔管可能会降低术后呼吸并发症的发生率。我们通过回顾性分析2004年1月至2006年6月期间所有接受OLT患者的数据,评估了我们患者在手术室(OR)中立即气管拔管的预测因素。根据患者是在OR中拔管(第1组,n = 52)还是在重症监护病房(ICU;第2组,n = 48),将患者分为两组。与第2组患者相比,第1组患者术前平均血清肌酐水平较低(0.9±1 vs 0.6±0.3 mg/dL,P = 0.04),术中输血需求量也较低(浓缩红细胞,35.5±29.8 vs 25.6±19.0 mL/kg;P = 0.05,新鲜冰冻血浆,33.1±15.6 vs 25.7±14.3 mL/kg;P = 0.01)。第2组术中低血压和急诊OLT的发生率明显高于第1组(分别为33.3% vs 13.5%,P = 0.01和45.8% vs 21.2%,P = 0.009)。经逻辑回归分析,只有急诊OLT(P = 0.009,比值比 = 3.5)和术中低血压(P = 0.018,比值比 = 3.7)与术后在OR中立即拔管的可能性较低显著相关。我们的结果表明,血流动力学稳定性和择期OLT是在OR中成功立即气管拔管的预测因素。