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Setting up for the block: the mechanism underlying lidocaine's use-dependent inhibition of sodium channels.

作者信息

Cummins Theodore R

机构信息

Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, 950 W. Walnut St, R2-Room 468, Indianapolis, IN 46202, USA .

出版信息

J Physiol. 2007 Jul 1;582(Pt 1):11. doi: 10.1113/jphysiol.2007.136671. Epub 2007 May 24.

DOI:10.1113/jphysiol.2007.136671
PMID:17525109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2075285/
Abstract
摘要

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本文引用的文献

1
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.结构域III和IV中S4片段的向外稳定增强了利多卡因对钠通道的阻滞作用。
J Physiol. 2007 Jul 1;582(Pt 1):317-34. doi: 10.1113/jphysiol.2007.134262. Epub 2007 May 17.
2
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.利多卡因结合位点残基苯丙氨酸-1759处的电荷变化影响人类心脏电压门控钠通道的通透性。
J Physiol. 2007 Jun 1;581(Pt 2):741-55. doi: 10.1113/jphysiol.2007.130161. Epub 2007 Mar 15.
3
Mechanism of local anesthetic drug action on voltage-gated sodium channels.局部麻醉药对电压门控性钠通道的作用机制。
Curr Pharm Des. 2005;11(21):2671-86. doi: 10.2174/1381612054546833.
4
Interactions of local anesthetics with voltage-gated Na+ channels.局部麻醉药与电压门控性钠离子通道的相互作用。
J Membr Biol. 2004 Sep 1;201(1):1-8. doi: 10.1007/s00232-004-0702-y.
5
Molecular action of lidocaine on the voltage sensors of sodium channels.利多卡因对钠通道电压感受器的分子作用。
J Gen Physiol. 2003 Feb;121(2):163-75. doi: 10.1085/jgp.20028651.
6
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.局部麻醉药：药物-受体反应的亲水和疏水途径。
J Gen Physiol. 1977 Apr;69(4):497-515. doi: 10.1085/jgp.69.4.497.